“It is time for the President to ask the Secretary of Health and Human Services to resign," said Sen. Lamar Alexander (R-Tenn.)

In a speech on the Senate floor on Tuesday, Alexander blasted Sebelius for the poor rollout of the federal insurance marketplace created by the Affordable Care Act.

“No private sector chief executive officer would escape accountability after such a poor performance,” he said.

Other lawmakers who have expressed frustration over the site, healthcare.gov, have merely called on Sebelius to act quickly to ensure that the online portal is fully functional as soon as possible. But Alexander said that someone else should be brought in to manage the turnaround.

“Expecting this secretary to be able to fix in a few weeks what she has not been able to fix during the last three and one half years is unrealistic,” he said. “It is throwing good money after bad.”

The embattled Sebelius will testify at a House Energy and Commerce Committee hearing Wednesday morning.